延缓前列腺癌的进展

1.生活方式的改变可以延缓前列腺癌的进展

患有前列腺癌的病人可以改变他们的饮食习惯和其他生活方式来改善他们的疾病状况，此说法来自发表于9月份的泌尿学杂志上的研究发现。

这个研究小组由Dean Ornish 医学博士领导，经设立对照组研究后发现完全的素食，结合锻炼及冥想，有助于降低前列腺抗原（PSA），和抑制前列腺癌细胞的生长。

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然而，研究者们也警告说：过于强烈地生活方式的改变对患者来说可能比较困难。他们也注意到，由于研究的时间不够长，现在还不能得出有利于生存期延长的证据。

百度同类结果：前列腺癌

Lifestyle Changes May Slow Progression of Prostate Cancer

Paula Moyer, MA

Men with prostate cancer who change their diet and make other lifestyle changes may also improve the course of their disease, according to investigators who published their findings in the September issue of The Journal of Urology.

The investigative team, headed by diet entrepreneur Dean Ornish, MD, found that a completely vegetarian diet, in combination with exercise and meditation, was associated with a reduction in baseline prostate specific antigen (PSA) and growth of prostate carcinoma cells with the experimental and control groups were compared.

"Changes in serum PSA and [prostate cancer] cell growth from baseline to 12 months were significantly different between the groups, showing more favorable changes in the experimental group," the authors wrote. "Specifically serum PSA decreased an average of 0.25 ng/ml or 4% of the baseline average in the experimental group but it showed an average increase of 0.38 ng/ml or 6% of the baseline average in the control group (P = 0.016)."

The investigators conducted the study to understand more clearly whether such changes could affect the course of prostate cancer. They recruited 93 men with early localized prostate cancer and randomly assigned them to usual care or to the experimental group, which underwent extensive lifestyle changes.

After following the men for a year, the investigators found that none of those in the experimental group but six in the control group underwent conventional prostate cancer treatment due to a rise in serum PSA. In addition to the changes in serum PSA and slowed growth of prostate cancer cells, the investigators also found that prostate cancer cell growth was inhibited nearly eight times more by serum from the experimental group than it was by serum from the controls (P < .001).

However, the investigators cautioned that the intensive lifestyle changes may be difficult to follow for patients. They also noted that due to the short duration of the study, the investigators could not associate the improved disease findings with any effect on survival.

J Urol. 2005;174:1065-1070

Reviewed by Gary D. Vogin, MD

American Urological Association^®

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